The Diverse Presentation Of Acute Leukemia - 1842 Words

Overview The diverse presentation of acute leukemia subtypes often makes specific disease subtypes difficult to recognize. Few, however, are as clinically challenging for the practicing hematologic malignancy physician to recognize as acute panmyelosis with myelofibrosis (APMF). APMF is a rare type of acute myeloid leukemia (AML) that manifests with a rapidly fibrotic bone marrow and progressive cytopenias. Early recognition is essential, as APMF can quickly turn fatal, a consequence of the disease’s ubiquitous pathologic features, aggressive clinical course, and poor response to traditional treatments. Pathologically this AML subtype is recognizable for its heavily fibrotic marrow, increased overall cellularity, immaturity of all cell-line lineages, abnormal megakaryocyte population, and lack of driver mutations. Clinical features include lack of spleen enlargement, bony pain, fevers and other features associated with systemic inflammation. In this chapter, we focus on how the hematologist and pathologist alike can best identify and manage the disease in light of the clinical challenges that accompany its rapid and progressive course. We discuss the background of this unique and deadly disease and what led to the identification of this disease from pathologically similar entities. Morphology and recognition of characteristic disease features, including immunophenotypic findings, cytogenetics and morphology are discussed. The identification and distinguishing features ofShow MoreRelatedAcute Lymphoblastic Leukemia ( All )2135 Words   |  9 PagesAcute lymphoblastic leukemia (ALL), a malignant disorder of lymphoid progenitor cells, is the most common hematological malignancy affects children, accounting for 25–30% of all childhood cancers with peak prevalence between the ages of 2 and 5 years [1]. The causes of pediatric acute leukemias are still not well known, the identification of causes and prevention/early intervention is clearly a worthwhile goal [2]. Previous studies have demonstrated that the interaction between genetic backgroundRead MoreBurkitts Lymphoma Disease Essay3211 Words   |  13 Pageswith Burkitt lymphoma. Dr. Burkitt was sending at the end of the World War II the military authorities to Africa. He was staying there and working as a doctor for many years. He saw there incurable malignant disease of children, similar to leukemia , tumors that appeared jaws, abdomen cavity and kidney. To make a map the spread of the disease, the doctor Burkitt drove by the car 15 thousand km on Africa. He found that the lymphoma sick only where the temperature never drops below 15 ° C. HeRead MoreEvaluating External Environment and Business Ethics: Samsung in Malaysia Case Study4568 Words   |  18 Pagesinto the environmental factors. An investigation by Kotha and Nair (1995) on the plan and environment as factors of presentation in the Japanese machine tool business designated that effectiveness and development of presentation were predisposed meaningfully by the environment. In addition to that, only ecological variables were connected with secure development of firm presentation. Recent stud y by OCass and Julian (2003) presented to Samsung that environmental features have an important influenceRead MoreSocm Study Guide Essay30404 Words   |  122 Pagesbones * Prevent over expansion of bladder Fluid Connective tissue – * Distinct population of cells suspended in a watery ground substance that contains dissolved proteins. Ex, blood and lymph Supporting Connective tissue – * Less diverse cell population * Matrix of dense ground substance and closely packed fibers * Either cartilage or bone * Hyaline Cartilage – most common * Stiff but slightly flexible * Support and reduces friction between bones Read MoreGsk Annual Report 2010135604 Words   |  543 PagesSee page 21. CER% represents growth at constant exchange rates. Sterling % or  £% represents growth at actual exchange rates. See page 21. The calculation of results before major restructuring is described in Note 1 to the ï ¬ nancial statements, ‘Presentation of the ï ¬ nancial statements’. GSK Annual Report 2010 01 We exist to improve the quality of human life by enabling people to do more, feel better and live longer. We work by respecting people, maintaining our focus on the patient and consumerRead More_x000C_Introduction to Statistics and Data Analysis355457 Words   |  1422 Pagesgreat care to provide precise deï ¬ nitions and clear examples of concepts that Advanced Placement Statistics instructors have acknowledged as difï ¬ cult for their students. We have also expanded the variety of examples and exercises, recognizing the diverse potential futures envisioned by very capable students who have not yet focused on a college major. Topic Coverage Our book can be used in courses as short as one quarter or as long as one year in duration. Particularly in shorter courses, an instructor